학력

최근 연구업적

• Nam KH, Yi SA, Nam G, Noh JS, Park JW, Lee MG, Park JH, Oh H, Lee J, Lee KR, Park HJ, Lee J, Han JW. Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer. BMC Cancer. 2019 Aug 6;19(1):773.
  
• Bahn G, Park JS, Yun UJ, Lee YJ, Choi Y, Park JS, Baek SH, Choi BY, Cho YS, Kim HK, Han J, Sul JH, Baik SH, Lim J, Wakabayashi N, Bae SH, Han JW, Arumugam TV, Mattson MP, Jo DG. NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12516-12523.
  
• Park JW, Han JW. Targeting epigenetics for cancer therapy. Arch Pharm Res. 2019 Feb;42(2):159-170. 
  
• Park J, Lee H, Han N, Kwak S, Lee HT, Kim JH, Kang K, Youn BH, Yang JH, Jeong HJ, Kang JS, Kim SY, Han JW, Youn HD, Cho EJ. Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization. Nucleic Acids Res. 2018 Dec 14;46(22):11759-11775. 
  
• Nam KH, Yi SA, Lee J, Lee MG, Park JH, Oh H, Lee J, Park JW, Han JW. Eudesmin impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1148-1153. 
  
• Choi BY, Choi Y, Park JS, Kang LJ, Baek SH, Park JS, Bahn G, Cho Y, Kim HK, Han J, Sul JH, Baik SH, Hyun DH, Arumugam TV, Yang S, Han JW, Kang YM, Cho YW, Park JH, Jo DG. Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis. Theranostics. 2018 Sep 9;8(17):4795-4804.
  
• Kim S, Park JW, Lee MG, Nam KH, Park JH, Oh H, Lee J, Han J, Yi SA, Han JW. Reversine promotes browning of white adipocytes by suppressing miR-133a. J Cell Physiol. 2019 Apr;234(4):3800-3813. 
  
• Kim MJ, Choi SK, Hong SH, Eun JW, Nam SW, Han JW, You JS. Oncogenic IL7R is downregulated by histone deacetylase inhibitor in esophageal squamous cell carcinoma via modulation of acetylated FOXO1. Int J Oncol. 2018 Jul;53(1):395-403.
  
• Yi SA, Lee J, Park JW, Han J, Lee MG, Nam KH, Park JH, Oh H, Ahn SJ, Kim S, Kwon SH, Jo DG, Han JW. S6K1 controls epigenetic plasticity for the expression of pancreatic α/β cell marker genes. J Cell Biochem. 2018 Aug;119(8):6674-6683.
  
• Lee H, Radu C, Han JW, Grailhe R.  Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells.  J Vis Exp. 2017 Oct 4;(128).
• Baek SH, Park SJ, Jeong JI, Kim SH, Han J, Kyung JW, Baik SH, Choi Y, Choi BY, Park JS, Bahn G, Shin JH, Jo DS, Lee JY, Jang CG, Arumugam TV, Kim J, Han JW, Koh JY, Cho DH, Jo DG.  Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model.  J Neurosci. 2017 May 17;37(20):5099-5110.
• Park DH, Kang GB, Kang DE, Hong JW, Lee MG, Kim KY, Han JW.  A new manufacturing process to remove thrombogenic factors (II, VII, IX, X, and XI) from intravenous immunoglobulin gamma preparations.  Biologicals. 2017 Jan;45:1-8.
• Lee SJ, Hwang J, Jeong HJ, Yoo M, Go GY, Lee JR, Leem YE, Park JW, Seo DW, Kim YK, Hahn MJ, Han JW, Kang JS, Bae GU.  PKN2 and Cdo interact to activate AKT and promote myoblast differentiation.  Cell Death Dis. 2016 Oct 20;7(10):e2431.
• Song CH, Yoon J, Ko N, Han JW.  Mapping the Technological Knowledge Landscape: The Case of Epigenetics.  Recent Pat Anticancer Drug Discov. 2016;11(4):424-433.
• Yang JH, Song TY, Jo C, Park J, Lee HY, Song I, Hong S, Jung KY, Kim J, Han JW, Youn HD, Cho EJ.  Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch.  Exp Mol Med. 2016 Aug 12;48:e252.
• Yi SA, Han J, Han JW.  Epigenetic role of nuclear S6K1 in early adipogenesis.  BMB Rep. 2016 Aug;49(8):401-2.
• Song CH, Han JW.  Patent cliff and strategic switch: exploring strategic design possibilities in the pharmaceutical industry.  Springerplus. 2016 May 23;5(1):692.
• Yi SA, Um SH, Lee J, Yoo JH, Bang SY, Park EK, Lee MG, Nam KH, Jeon YJ, Park JW, You JS, Lee SJ, Bae GU, Rhie JW, Kozma SC, Thomas G, Han JW.  S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.  Mol Cell. 2016 May 5;62(3):443-452.

연구부문

• Epigenetic mechanism in gene transcription
• Investigation of novel epigenome modulator
• Epigenetic regulation of developmental processes
• Signal transduction (p70s6k, mTOR)