교수/연구실 소개

>대학소개 >교수/연구실 소개

전임교수

김 인 수In Su Kim

전공의약품합성학, 약학연구설계론
사무실No. 530702
031-290-7788
연구실No. 530704
031-299-4373
e-mailinsukim@skku.edu

이메일insukim@skku.edu
홈페이지pharmasyn.skku.edu
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학력/경력

최근 연구업적

Lee, H.; Kang, D.; Han, S. H.; Chun, R.; Pandey, A. K.; Mishra, N. K.; Hong, S.; Kim, I. S.* “Allylic Acetals as Acrolein Oxonium Precursors in Tandem C-H Allylation and [3+2] Dipolar Cycloaddition” Angew. Chem., Int. Ed. 2019, submitted for publication.
Chun, R.; Kim, S.; Han, S. H.; Han, S.; Lee, S. H.; Mishra, N. K.; Jung, Y. H.; Kim, H. S.; Kim, I. S.* “Synthesis of (2H)-Indazoles from Azobenzenes Using Paraformaldehyde as One Carbon Synthon” Adv. Synth. Catal. 2019, 360, 1617-1626.
Yang, H. Y.; Kim. K. S.; Lee, Y. H.; Park, J. H.; Kim, J.-H.; Lee, S.-Y.; Kim, Y.-M.; Kim, I. S.; Kacew, S.; Lee, B. M.; Kwak, J. H.; Yoon, K.; Kim, H. S. “Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways” Int. J. Biol. Sci. 2019, 15, 800-811.
Lee S. H.; Jeong, T.; Kim, K.; Kwon, N. Y.; Pandey, A. K.; Kim, H. S.; Ku, J.-M.; Mishra, N, K.; Kim, I. S.* “Ruthenium(II)-Catalyzed Site-Selective Hydroxymethylation of Indolines with Paraformaldehyde” J. Org. Chem. 2019, 84, 2307-2315 (selected as a Cover Page of JOC).
De, U.; Son, J. Y.; Jeon, Y.; Ha, S. Y.; Park, Y. J.; Yoon, S.; Ha, K.-T.; Choi, W. S.; Lee, B. M.; Kim, I. S.; Kwak, J. H.; Kim, H. S. “Plumbagin from a tropical pitcher plant (Nepenthes alata Blanco) induces apoptotic cell death via a p53-dependent pathway in MCF-7 human breast cancer cells” Food Chem. Toxicol. 2018, 123, 492-500.
Sachan, R.; Kundu, A.; Jeon, Y.; Choi, W. S.; Yoon, K.; Kim, I. S.; Kwak, J. H.; Kim, H. S. “Afrocyclamine A, a triterpenoid saponin, induces apoptosis and autophagic cell death via the PI3k/Akt/mTOR pathway in human prostate cancer cells" Phytomedicine 2018, 51, 139-150.
Mishra, N. K.; Park, J.; Oh, H.; Han, S. H.; Kim, I. S.* “Recent Advances in N-Heterocycles Synthesis through Catalytic C-H Functionalization of Azobenzenes” Tetrahedron 2018, 74, 6769-6794.
Han, S. H.; Pandey, A. K.; Lee, H.; Kim, S.; Kang, D.; Jung, Y. H.; Kim, H. S.; Hong, S.; Kim, I. S.* “A New Synthetic Histone Deacetylase Inhibitor, MHY2256, Induces Apoptosis and Autophagy Cell Death in Endometrial Cancer Cells via p53 Acetylation” Int. J. Mol. Sci. 2018, 19, 2743-2744.
Chun, R.; Kim, S.; Han, S. H.; Pandey, A. K.; Mishra, N. K.; Kim, I. S.* “Site-Selective C-H Nitration of N-Aryl-7-Azaindoles Under Palladium(II) Catalysis” Tetrahedron Lett. 2018, 59, 3848-3852.
Kim, S.; Kundu, A.; Chun, R.; Han, S. H.; Pandey, A. K.; Yoo, S.; Park, J.; Kim, H.; Ku, J.-M.; Kim, I. S.* “Direct Synthesis of 2-Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti-inflammatory Activity” Asian J. Org. Chem. 2018, 7, 2069-2075 (selected as Cover Page of AJOC).
Han, S.; Chakrasali, P; Park, J.; Oh, H.; Kim, S.; Kim, K.; Pandey, A. K.; Han, S. H.; Han, S. B.; Kim, I. S.* “Reductive C2-Alkylation of Pyridine- and Quinoline-N-Oxides Using Wittig Reagents” Angew. Chem., Int. Ed. 2018, 57, 12737-12740.
Pandey, A. K.; Kang, D.; Han, S. H.; Lee, H.; Mishra, N. K.; Kim, H. S.; Jung, Y. H.; Hong, S.; Kim, I. S.* “Reactivity of Morita-Baylis-Hillamn Adducts in C-H Functionalization of (Hetero)aryl Nitrones: Access to Bridged Cycles and Carbazoles” Org. Lett. 2018, 20, 4632-4636.
Kim, S.; Han, S. H.; Mishra, N. K.; Chun, R.; Jung, Y. H.; Kim H. S.; Park, J. S.; Kim, I. S.* “Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines" Org. Lett. 2018, 20, 4010-4014.
Park, J. S.; Park, J.; Yang, Y. J.; Tran, T. T.; Kim, I. S.*; Sessler, J. L. “Disparate Downstream Reactions Mediated by an Ionically Controlled Supramolecular Tristate Switch” J. Am. Chem. Soc. 2018, 140, 7598-7604 (selected as Cover Page of JACS).
Jeong, T.; Lee, S. H.; Chun, R.; Han, S.; Han, S. H.; Jeon, Y. U.; Park, J.; Yoshimitsu, T.; Mishra, N. K.; Kim, I. S.* “Ru(II)-Catalyzed C-H Aminocarbonylation of N-(Hetero)aryl-7-azaindoles with Isocyanates” J. Org. Chem. 2018, 83, 4641-4649.
Oh, H.; Han, S.;, Pandey, A. K.; Han, S. H.; Mishra, N. K.; Kim, S.; Chun, R.; Kim, H. S.; Park, J.; Kim, I. S.* “Synthesis of (2H)-Indazoles through Rh(III)-Catalyzed Annulation Reaction of Azobenzenes with Sulfoxonium Ylides” J. Org. Chem. 2018, 83, 4070-4077.
Lee, S. H.; Kundu, A.; Han, S. H.; Mishra, N. K.; Kim, K. S.; Choi, M. H.; Pandey, A. K.; Park, J. S.; Kim, H. S.; Kim, I. S.* “Synthesis of TMPA derivatives through sequential Ir(III)-catalyzed C-H alkylation and their antidiabetic evaluation” ACS Omega 2018, 3, 2661-2672.
Pandey, A. K.; Han, S. H.; Mishra, N. K.; Kang, D.; Lee, S. H.; Chun, R.; Hong, S.; Park, J. S.; Kim, I. S.* “Synthesis of 2-Benzazepines from Benzylamines and MBH Adducts Under Rhodium(III) Catalysis via C(sp2)-H Functionalization” ACS Catal. 2018, 8, 742-746.
Oh, Y.; Jang, Y. J.; Jeon, M.; Kim, H. S.; Kwak, J. H.; Chung, K. H.; Pyo, S.; Jung, Y. H.; Kim, I. S.* “Total Synthesis and Anti-inflammatory Evaluation of Penchinone A and Its Structural Analogues” J. Org. Chem. 2017, 82, 11566-11572.

수행과제

단일단계 탄소-수소 변환을 통한 신규 아미노산의 합성 및 기능화 연구 (한국연구재단)
레이트스테이지 약물 최적화 연구실(BRL) (한국연구재단)
신약 후보 물질 발굴을 위한 화합물 라이브러리 구축 연구
천연물신약 후보물질 개발
신규 kinase 유도체 합성 연구
합성바이오소재 고출을 위한 신규 합성기술 개발
신규 결정형 통풍 치료 제네릭 의약품 개발
퇴행성 관절염 치료를 위한 선택적 COX-2 억제제 제네릭 의약품 개발
합성바이오소재 합성 연구

연구부문

1. Development of New Synthetic Methodology Based on Transition-Metal Chemistry Catalytic C-C or C-X Bond formation via C-H Bond Activation Catalytic Organic Transformations for Chiral Building Blocks Synthesis of Higher Value-added Materials from Various Feedstocks
2. Total Synthesis of Biologically Active Natural Products
3. Synthesis of Organocatalyst and Application to New Synthetic Methodology

성균관대학교 약학대학

skku school of pharmacy

교수/연구실 소개

김 인 수In Su Kim

학력

주요경력

최근 연구업적

수행과제

연구부문