교수/연구실 소개
>대학소개 >교수/연구실 소개
권 용 석Yong Seok Kwon
- 전공촉매 약화학
- 사무실NO. 530736
031-290-7713 - 연구실NO. 530729
031-290-7767 - e-maily.kwon@skku.edu
학력
2005.03 ~ 2009.02 충북대학교 약학대학 제약학과 약학사
2009.03 ~ 2011.02 서울대학교 약학대학 약학과 약학석사
2011.03 ~ 2016.02 서울대학교 약학대학 약학과 약학박사
주요경력
- 2016.03 ~ 2016.07 서울대학교 약학대학 박사 후 연구원
- 2016.07 ~ 2019.08 예일대학교 화학과 박사 후 연구원
- 2019.09 ~ 2021.08 서강대학교 화학과 조교수
- 2021.08 ~ 성균관대학교 약학대학 조교수
최근 연구업적
- Kim, A.†; Kim, A.†; Park, S.; Kim, S.; Jo, H.; Ok, K. M.; Lee, S. K.; Song, J.; Kwon, Y.* “Catalytic and Enantioselective Control of the C−N Stereogenic Axis via the Pictet-Spengler Reaction” Angew. Chem. Int. Ed. 2021, 60(22), 12279‒12283.
- Featherston, A. L.†; Kwon, Y.†; Pompeo, M. M.†; Engl, O. D.; Leahy, D. K.*; Miller, S. J.* “Catalytic Asymmetric and Stereodivergent Oligonucleotide Synthesis” Science 2021, 371(6530), 702‒707; ChemRxiv (preprint), posted on 28.10.2020. (†equally contributed first authors)
- Yang, J.; Lee, S. J.; Kwon, Y.; Ma, L.; Kim, J.* “Tumor suppressive function of Matrin 3 in the basal-like breast cancer” Biol. Res., 2020, 53, 42.
- Kim, S. B.; Lee, T.; Moon, H. S.; Ki, S. H.; Oh, Y. S.; Lee, J.-Y.; Kim, S.-B.; Park, J.-E.; Kwon, Y.; Kim, S.; Baek, D. J.*; Park, E.-Y.* “Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity” Molecules 2020, 25(11), 2484.
- Shrestha, J.; Hwang, G. T.; Lee, T.; Kim, S. W.; Oh Y. S.; Kwon, Y.; Hong, S. W.; Kim, S.; Moon, H. S.; Baek, D. J.*; Park, E.-Y.* “Synthesis and Biological Evaluation of BODIPY-PF-543” Molecules 2019, 24(23), 4408.
- Kwon, Y.; Li, J.; Reid, J. P.; Crawford, J. M.; Jacob, R.; Sigman, M. S.*; Toste, F. D.*; Miller, S. J.* “Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration” J. Am. Chem. Soc. 2019, 141, 6698‒6705.
- Kwon, Y.; Chinn, A. J.; Kim, B.; Miller, S. J.* “Divergent Control of Point and Axial Stereogenicity: Catalytic Enantioselective C−N Bond-Forming Cross-Coupling and Catalyst-Controlled Atroposelective Cyclodehydration” Angew. Chem. Int. Ed. 2018, 57(21), 6251‒6255. This publication was denoted as ‘VIP’ (Very Important paper) in Angewandte Chemie, and also highlighted in Chemistry Views.
- Chinn, A. J.; Kim, B.; Kwon, Y.; Miller, S. J.* “Enantioselective Intermolecular C–O Bond Formation in the Desymmetrization of Diarylmethines Employing a Guanidinylated Peptide-Based Catalyst” J. Am. Chem. Soc. 2017, 139(49), 18107‒18114.
- Yu, S.; Oh, J.; Li, F.; Kwon, Y.; Cho, H.; Shin, J.; Lee, S. K.*; Kim, S.* “New Scaffold for Angiogenesis Inhibitors Discovered by Targeted Chemical Transformations of Wondonin Natural Products” ACS Med. Chem. Lett. 2017, 8(10), 1066‒1071.
- Park, H.; Kwon, Y.; Shin, J. E.; Kim, W.-J.; Hwang, S.; Lee, S.; Kim, S.* “Orthoester in Cyclodehydration of Carbamate-Protected Amino Alcohols under Acidic Conditions” Synthesis 2017, 49(12), 2761‒2767.
- Kwon, Y.†; Jung, J.†; Kim, J. H.; Kim, W.-J.; Kim, S.* “Amide Acetal in Palladium-Catalyzed Allylation with Allylic Alcohols under Neutral Conditions” Asian J. Org. Chem. 2017, 6(5), 520‒526. (†equally contributed first authors)
- Kwon, Y.†; Song, J.†; Lee, H.; Kim, E.-Y.; Lee, K.; Lee, S. K.*; Kim, S.* “Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents” J. Med. Chem. 2015, 58(19), 7749‒7762. (†equally contributed first authors)
- Song, J.; Kwon, Y.; Kim, S.; Lee, S. K.* “Antitumor Activity of Phenanthroindolizidine Alkaloids Is Associated with Negative Regulation of Met Endosomal Signaling in Renal Cancer Cells” Chem. Biol. 2015, 22(4), 504‒515