skku school of pharmacy
박 현 주Hyun Ju Park
학력
1989 : 서울대학교 제약학 학사 1991 : 서울대학교 대학원 약학과 석사 1997 : The University of Texas at Austin, 의약화학 박사
주요경력
1997 - 2000 : Massachusetts Institute of Technology 화학과, Postdoctoral Associate 2000 - 2004 : 성균관대학교 약학대학 조교수 2004 - 2010 : 성균관대학교 약학대학 부교수 2011 - 현재 : 성균관대학교 약학대학 교수
최근 연구업적
Kim HS, Hong M, Ann J, Yoon S, Nguyen CT, Lee SC, Lee HY, Suh YG, Seo JH, Choi H, Kim JY, Kim KW, Kim J, Kim YM, Park SJ, Park HJ, Lee J. Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors. Bioorg Med Chem. 2016 Nov 15;24(22):6082-6093. Kim K, Park JM, Kim NJ, Kim SJ, Moon H, An H, Lee J, Park HJ, Surh YJ, Suh YG. Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14 -PGJ2 . Chembiochem. 2016 Oct 17;17(20):1900-1904. Yoo J, Kim SJ, Son D, Seo H, Baek SY, Maeng CY, Lee C, Kim IS, Jung YH, Lee SM, Park HJ. Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity. Eur J Med Chem. 2016 Jun 30;116:126-135. Son D, Kim CS, Lee KR, Park HJ. Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay. Bioorg Med Chem Lett. 2016 May 1;26(9):2365-9. Kim SJ, Baek KS, Park HJ, Jung YH, Lee SM. Compound 9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury in mice by suppressing MAPK signalling. Br J Pharmacol. 2016 Mar;173(6):1045-57. Cho S, Im H, Lee KY, Chen J, Kang HJ, Yoon HJ, Min KH, Lee KR, Park HJ, Lee BJ. Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS). Eur J Med Chem. 2016 Jan 27;108:188-200
수행과제
당뇨병 치료제 후보물질인 새로운 GPCR 효능제 선도물질 개발 (한국연구재단) 메르스(MERS) 치료물질 개발을 위한 가상검색 및 분자설계 (경기도) 이중 표적 신약연구
연구부문
Structure-based virtual screening of chemical database and identification of hit compounds by biophysical analyses (targets: epigenome modulators (HDACs, HMT, DNMT), Z-DNA binding protein, RNA pseudoknot and stem-loop, G-quadruplex, kinases, and etc.) 3D-QSAR/QSPR studies on various bioactive compounds Studies on the molecular mechanism of cisplatin resistance in gastric cancer Identification of G-quadruplex binding proteins and their biological function
