교수/연구실 소개
>대학소개 >교수/연구실 소개
김 충 섭Chung Sub Kim
- 전공생약학/천연물신약론
- 사무실NO. 530538
031-290-7727 - 연구실NO. 530739
031-290-7750 - e-mailchungsub.kim@skku.edu
학력
- 2006-2010 : 성균관대학교 약학대학 약학과 약학사
- 2010-2015 : 성균관대학교 약학대학 약학과 약학박사
주요경력
- 2015-2016 : Postdoctoral Researcher, School of Pharmacy, Sungkyunkwan University
- 2016-2020 : Postdoctoral Associate, Department of Chemistry, Yale University, USA
최근 연구업적
First-authored
Kim, C. S.*; Li, J. –H.*; Barco, B.; Wei, Z.; Park, H. B.; Wang, R.; Wyche, T. P.; Piizzi, G.; Clay, N. K.; Crawford, J. M. Cellular stress upregulates indole signaling metabolites in E. coli. Cell Chem. Biol. accepted (IF: 6.762)
Kim, C. S.; Gatisos, A.; Cuesta, S.; Yick, C. L.; Wei, Z.; Chen, H.; Russell, R. M.; Shine, E. E.; Wang, R.; Wyche, T. P.; Piizzi, G.; Flavell, R. A.; Palm, N. W.; Sperandio, V.; Crawford, J. M. Characterization of autoinducer-3 structure and biosynthesis in E. coli. ACS Cent. Sci. 2020, in press. (IF: 12.837) – Highlighted in Yale News (https://westcampus.yale.edu/news/scientists-zero-endgame-nasty-bacteria?refresh=2)
Xue, M.*; Kim, C. S.*; Healy, A. R.; Wernke, K. M.; Wang, Z.; Frischling, M. C.; Shine, E. E.; Wang, W.; Herzon, S. B.#; Crawford, J. M.# Structure elucidation of colibactin and its DNA cross-links. Science 2019, 365, eaax2685. (IF: 41.063) – Highlighted in Nat. Chem. Biol. (2019, 15, 933), Chemical & Engineering News (https://cen.acs.org/biological-chemistry/microbiome/Researchers-elucidate-colibactin-structure/97/i32) and Yale News (https://westcampus.yale.edu/yale-scientists-zero-atomic-driver-tumor-formation)
Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Rare thioglycosides from the roots of Wasabia japonica. J. Nat. Prod. 2018, 81, 2129-2133. (IF: 4.257)
Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Structural characterization of terpenoids from Abies holophylla using computational and statistical methods and their biological activities. J. Nat. Prod. 2018, 81, 1795-1802. (IF: 4.257)
Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Two new phenolic glycosides from Sorbus commixta. Chem. Pharm. Bull. 2018, 66, 839-842. (IF: 1.405)
Kim, C. S.; Subedi, L.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R. A new phenolic compound from Salix glandulosa. Heterocycles 2018, 96, 931-942. (IF: 0.878)
Kim, C. S.; Subedi, L.; Oh, J.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Bioactive triterpenoids from the twigs of Chaenomeles sinensis. J. Nat. Prod. 2017, 80, 1134-1140. (IF: 4.257)
Kim, C. S.; Bae, M.; Oh, J.; Subedi, L.; Suh, W. S.; Choi, S. Z.; Son, M. W.; Kim, S. Y.; Choi, S. U.; Oh, D.–C.; Lee, K. R. Anti-neurodegenerative biflavonoid glycosides from Impatiens balsamina. J. Nat. Prod. 2017, 80, 471-478. (IF: 4.257)
Kim, C. S.; Oh, J.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Holophyllane A: A triterpenoid possessing an unprecedented B-nor-3,4-seco-17,14-friedo-lanostane architecture from Abies holophylla. Sci. Rep. 2017, 7, 43646. (IF: 4.011)
Kim, C. S.; Oh, J.; Suh. W. S.; Jang, S. W.; Subedi, L.; Kim, S. Y.; Lee, K. R. Investigation of chemical constituents from Spiraea prunifolia var. simpliciflora and their biological activities. Phytochem. Lett. 2017, 22, 255-260. (IF: 1.338)
Kim, C. S.; Subedi, L.; Kwon, O. W.; Park, H. B.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R. Wasabisides A-E, lignan glycosides from the roots of Wasabia japonica. J. Nat. Prod. 2016, 79, 2652-2657. (IF: 4.257)
Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R. Diterpenes from the trunk of Abies holophylla and their potential neuroprotective and anti-inflammatory activities. J. Nat. Prod. 2016, 79, 387-394. (IF: 4.257)
Kim, C. S.; Suh. W. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Lee, K. R. Neuroprotective fatty acids from the stem bark of Sorbus commixta. Lipids 2016, 51, 989-995. (IF: 2.144)
Kim, C. S.; Subedi, L.; Kwon, O. K.; Kim, S. Y.; Yeo, E. –J.; Choi, S. U.; Lee, K. R. Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis. Bioorg. Med. Chem. Lett. 2016, 26, 351-354. (IF: 2.448)
Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R. Lignan glycosides from the twigs of Chaenomeles sinensis and their biological activities. J. Nat. Prod. 2015, 78, 1174-1178. (IF: 4.257)
Kim, C. S.; Moon, E.; Choi, S. U.; Kim, S. Y.; Lee, K. L.; Kim, K. H. Cytotoxic and anti-inflammatory disulfide compounds from the fruiting bodies of Boletus pseudocalopus. J. Antibiot. 2015, 68, 414-416. (IF: 2.446)
Kim, C. S.; Subedi, L.; Kim, S. Y.; Choi, S. U.; Choi, S. Z.; Son, M. W.; Kim, K. H.; Lee, K. R. Two new phenolic compounds from the white flower of Impatiens balsamina. Phytochem. Lett. 2015, 14, 215-220. (IF: 1.338)
Kim, C. S.; Subedi, L.; Park, K. J.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R. Salicin derivatives from Salix glandulosa and their biological activities. Fitoterapia, 2015, 106, 147-152. (IF: 2.431)
Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Kim, J. Y.; Han, J. Y.; Choi, S. I.; Choi, J. G.; Kim, K. H.; Lee, K. R. Phenolic Glycosides from the Twigs of Salix glandulosa. J. Nat. Prod. 2014, 77, 1955-1961. (IF: 4.257)
Kim, C. S.; Shin, B.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Oh, D. C.; Kim, K. H.; Lee, K. R. Holophyllin A, a rearranged abietane-type diterpenoid from the trunk of Abies holophylla. Tetrahedron Lett. 2014, 55, 6504-6507. (IF: 2.259)
Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Choi, S. U.; Kim, K. H.; Lee, K. R. Five new oxylipins from Chaenomeles sinensis. Lipids 2014, 49, 1151-1159. (IF: 2.144)
Kim, C. S.; Suh, W. S.; Choi, S. U.; Kim, K. H.; Lee, K. R. Two new diterpenoids from Thuja orientalis and their cytotoxicity. Bull. Korean Chem. Soc. 2014, 35, 2855-2858. (IF: 0.602)
Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Kim, K. H.; Lee, K. R. A new cyclic triterpene saponin from Phyteuma japonicum. Heterocycles 2014, 89, 1913-1922. (IF: 0.878)
Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Lee, K. R. Flavonoid glycosides from Hosta longipes, their inhibition on NO production, and nerve growth factor inductive effects. J. Braz. Chem. Soc. 2014, 25, 907-912. (IF: 1.335)
Kim, C. S.; Kim, K. H.; Lee, K. R. Phytochemical constituents of the leaves of Hosta longipes. Nat. Prod. Sci. 2014, 20, 86-90.
Kim, C. S., Kim, S. Y.; Moon, E.; Lee, M. K.; Lee, K. R. Steroidal constituents from the leaves of Hosta longipes and their inhibitory effects on nitric oxide production. Bioorg. Med. Chem. Lett. 2013, 23, 1771-1775. (IF: 2.448)
Kim, C. S.; Kwon, O. W.; Kim, S. Y.; Lee, K. R. Bioactive lignans from the trunk of Abies holophylla. J. Nat. Prod. 2013, 76, 2131-2135. (IF: 4.257)
Kim, C. S.; Oh, J. Y.; Choi, S. U.; Lee, K. R. Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity. Carbohyd. Res. 2013, 381, 1-5. (IF: 1.873)
Kim, C. S.; Choi, S. U.; Lee, K. R. Three new diterpenoids from the leaves of Thuja orientalis. Planta Med. 2012, 78, 485-487. (IF: 2.746)
연구부문
- Elucidation of structure and biosynthetic pathway of small molecules from human microbiome.
- Characterization of small molecules-mediated bacterial signaling pathways
- Discovery of lead compounds for new drug from natural sources
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