학력

• Ph.D. in Microbiology, Cornell University, 2014
• Dissertation Tiles: Carbon and Lipid Metabolism in Mycobacterium tuberculosis (Professor David G. Russell)

  
  

최근 연구업적

• Taguchi A, Welsh MA, Marmont LS, Lee W, Kahne D, Bernhardt TD and Walker S. Reconstitution of septal peptidoglycan synthesis reveals requirements for cell wall synthase activity. Nature Microbiology  2019 DOI: 10.1038/s41564-018-0345-x. 

• *Santiago M, *Lee W, Fayad AA, Coe KA, Rajagopal M, Do T, Hennessen F, Srisuknimit V, Müller R, Meredith TC, Walker S. Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic. Nature Chemical Biology. 2018 Jun;14(6):601-608. *co-first: equally contributed.

•  Lee W, Do T, Zhang G, Kahne D, Meredith TC, Walker S. Antibiotic Combinations That Enable One-Step, Targeted Mutagenesis of Chromosomal Genes. ACS Infectious Diseases. 2018, 4 (6), 1007–1018 

• Matano L*, Morris H*, Hesser A*, Martin S, Lee W, Owens T, Laney E, Villet R, Hooper D, Meredith T. Walker S. An antibiotic that inhibits the ATPase activity of an ABC transporter by binding to a remote extracellular site, J Am Chem Soc. 2017 Jul 20. doi: 10.1021. *equally contributed

• Nazarova VE, Montague CR, La T, Wilburn KM, Sukumar N, Lee W, Caldwell S, Russell DG, and VanderVen BC. Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis. Elife. 2017 Jun 27;6.

•  Lee W, VanderVen BC, Walker S, Russell DG. Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis. Scientific Reports. 2017 Dec;7(1):72.     

•  Pajagopal M*, Martin MJ*, Santiago M*, Lee W, Kos VN, Meredith T, Gilmore MS, Walker S. Multidrug intrinsic resistance factors in Staphylococcus aureus identified by profiling fitness within high-diversity transposon libraries. mBio. 2016 7(4):e00950-16. DOI:10.1128. *equally contributed 

• Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S. The mechanism of action of lysobactin. J Am Chem Soc. 2016 Jan 13;138(1):100-3. doi: 10.1021.  

• Pasquina L, Santa Maria JP Jr, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nature Chemical Biology. 2016 Jan;12(1):40-5.

•  VanderVen BC, Fahey FJ, Lee W, Yancheng Liu, Abramovitch RB, Memmott C, Crowe AM, Eltis LD, Perola E, Deininger DD, Wang T, Locher CP, and Russell DG. Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment. PLoS Pathogens. 2015 11(2): e1004679. PMID: 25675247

연구부문

• Bacterial Cell Genomics using Tn-seq, NGS, and Machine Learning
• Study of Antibiotic Resistance Bacterial Cell
• Study of Gram-Positive Bacterial Cell Wall and its Regulation
• Study of Bacterial Physiology and Energy Metabolism using Metabolomics and Metabolic Flux Analysis