교수/연구실 소개
>대학소개 >교수/연구실 소개
이 석 용Seok Yong Lee
- 전공약리학, 임상약리학, 약물치료학
- 사무실No. 530438
031-290-7718 - 연구실No. 530430
031-290-7758 - e-mailsylee@skku.edu
학력
- 1982 : 성균관대학교 약학과 (약학사)
- 1984 : 성균관대학교 대학원 약학과 (약학석사, 약물학전공)
- 1989 : 가톨릭의과대학 대학원 (의학박사, 약리학전공)
주요경력
- 1. 교육경력
- 1982.3 - 1982.8 : 성균관대학교 약학대학 조교
- 1982.9 - 1988.2 : 가톨릭의과대학 약리학교실 조교
- 1988.3 - 1997.8 : 가톨릭의과대학 약리학교실 전임강사, 조교수, 부교수
- 1993.9 - 1995.6 : 미국 미네소타대학교 의과대학 교환교수
- 1997.9 - 2002.3 : 성균관대학교 약학대학 부교수 (약물학)
- 2002.4 - 현재 : 성균관대학교 약학대학 교수 (약물학)
- 2. 교내활동
- 성균관대학교 교과과정심의위원회 위원 (1998-2000)
- 성균관대학교 약학과 학과장 (2002-2004)
- 성균관대학교 자연과학캠퍼스발전기획위원회 위원 (2005-2007)
- 성균관대학교 예산결산자문위원회 위원 (2005-2007)
- 성균관대학교 공동기기운영위원회 위원 (2007-2013)
- 성균관대학교 기숙사 학사장 (2008-2010)
- 성균관대학교 Vision 2010+ 평가위원회 위원 (2010-2011)
- (현) 성균관대학교 임상약학대학원 학과장 (1999.3 - )
- (현) 성균관대학교 생명윤리위원회 부위원장 (2012.8 - )
- 3. 교외활동
- 가톨릭의과대학 외래교수 (1998-2006)
- 대한약사회 약학위원회 위원 (1998-2000)
- 보건복지부 의약품분류위원회 위원 (1999-2000)
- 학교법인 앞선학원 재단이사 (2004- )
- 대한약리학회 이사(2001-2004),상임이사(2005-2014), 재무이사(2007-2010)
- 식품의약품안전평가원 R&D기획단 운영위원 (2010)
- 삼성서울병원 임상시험심사위원회 심사위원(2010-2013)
- 대한약학회 임상약학특별위원회 위원 (2011-2012)
- 대한약학회 약물학분과회 회장 (2012)
- 대한약리학회 총무이사 (2013-2014)
- 대한약학회 교육위원장 (2013-2014)
- (현) Archives of Pharmacal Research (SCI저널) Editor-in-Chief (2015- )
- (현) 성균관대학교 총동창회 부회장 (2011 - )
- (현) 식약처 중앙약사심의위원회 위원 (1998.1 - )
- (현) 식품의약품안전평가원 전문가 자문위원 (2009.10 - ), 의약품심사자문단(2013- ), 생동성관리정책자문단(2014- )
- (현) 식품의약품안전청 의약품재분류 자문위원 (2011 - )
- (현) 건강보험심사평가원 약제급여평가위원회 심사위원(2013.7 - ), 약리부 심사위원 (2004.8 - )
- (현) 한국약학교육협의회 약사고시위원회 부위원장 (2014 - )
- (현) 미국약리학회(ASPET) 정회원
- (현) 미국임상약리학회(ASCPT) 정회원
최근 연구업적
- Byeon JY, Kim YH, Kim SH, Lee CM, Choi CI, Bae JW, Jang CG, Lee SY, Lee YJ. Inhibition of salivary secretion by tolterodine transdermal patch. Arch Pharm Res. 2017 Nov 20.
- Kim YH, Byeon JY, Kim SH, Lee CM, Jung EH, Chae WK, Jang CG, Lee SY, Lee YJ. Simultaneous determination of tolterodine and its two metabolites, 5-hydroxymethyltolterodine and N-dealkyltolterodine in human plasma using LC-MS/MS and its application to a pharmacokinetic study. Arch Pharm Res. 2017 Nov;40(11):1287-1295.
- Hong SI, Nguyen TL, Ma SX, Kim HC, Lee SY, Jang CG. Corrigendum to "TRPV1 modulates morphine-induced conditioned place preference via p38 MAPK in the nucleus accumbens" [Behav. Brain Res. 334 (2017) 26-33]. Behav Brain Res. 2018 Feb 15;338:185.
- Ko YH, Kwon SH, Lee SY, Jang CG. Liquiritigenin ameliorates memory and cognitive impairment through cholinergic and BDNF pathways in the mouse hippocampus. Arch Pharm Res. 2017 Oct;40(10):1209-1217.
- Hong SI, Nguyen TL, Ma SX, Kim HC, Lee SY, Jang CG. TRPV1 modulates morphine-induced conditioned place preference via p38 MAPK in the nucleus accumbens. Behav Brain Res. 2017 Sep 15;334:26-33.
- Oh MJ, Hwang HH, Kim HG, Lee GH, Cho YS, Lee SY, Kang SY, Cho KH, Lee YY, Lee YJ, Jang CG, Lee SY. Bioequivalence Study of a New Fixed-dose Combination Tablet Containing S-Amlodipine Nicotinate and Olmesartan Medoxomil in Healthy Korean Male Subjects. Clin Ther. 2017 Jul;39(7):1371-1379.
- Ko YH, Kwon SH, Hwang JY, Kim KI, Seo JY, Nguyen TL, Lee SY, Kim HC, Jang CG. The Memory-Enhancing Effects of Liquiritigenin by Activation of NMDA Receptors and the CREB Signaling Pathway in Mice. Biomol Ther (Seoul). 2017 May 30.
- Oh JH, Hwang JY, Hong SI, Ma SX, Seo JY, Lee SY, Kim HC, Jang CG. The new designer drug buphedrone produces rewarding properties via dopamine D1 receptor activation. Addict Biol. 2016 Oct 27.
- Ma SX, Kwon SH, Seo JY, Hwang JY, Hong SI, Kim HC, Lee SY, Jang CG. Impairment of opiate-mediated behaviors by the selective TRPV1 antagonist SB366791. Addict Biol. 2017 Nov;22(6):1817-1828.
- Lee HJ, Kim YH, Kim SH, Lee CM, Yang AY, Jang CG, Lee SY, Bae JW, Choi CI. Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of zafirlukast. Arch Pharm Res. 2016 Jul;39(7):1013-9.
- Kwon SH, Ma SX, Ko YH, Seo JY, Lee BR, Lee TH, Kim SY, Lee SY, Jang CG. Vaccinium bracteatum Thunb. Exerts Anti-Inflammatory Activity by Inhibiting NF-κB Activation in BV-2 Microglial Cells. Biomol Ther (Seoul). 2016 Sep 1;24(5):543-51.
- Jiang F, Kim HD, Na HS, Lee SY, Seo DW, Choi JY, Ha JH, Shin HJ, Kim YH, Chung MW.
The influences of CYP2D6 genotypes and drug interactions on the pharmacokinetics of venlafaxine: exploring predictive biomarkers for treatment outcomes. Psychopharmacology (Berl). 2014 Dec 17. [Epub ahead of print] - Jung YH, Hong SI, Ma SX, Hwang JY, Kim JS, Lee JH, Seo JY, Lee SY, Jang CG. Strain differences in the chronic mild stress animal model of depression and anxiety in mice. Biomol Ther 22(5):453-9, 2014
- Lee HI, Choi CI, Byeon JY, Lee JE, Park SY, Kim YH, Kim SH, Lee YJ, Jang CG, Lee SY. Simultaneous determination of flurbiprofen and its hydroxy metabolite in human plasma by liquid chromatography-tandem mass spectrometry for clinical application. J Chromatogr B. 971, 58-63, 2014.
- Lee HI, Choi CI, Sa JH, Lee YJ, Bae JW, Jang CG, Lee SY. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1alpha, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Aug 20.
- Lee HI, Bae JW, Choi CI, Lee YJ, Byeon JY, Jang CG, Lee SY. Response to Suarez-Kurtz's comments on strongly increased exposure of meloxicam in CYP2C9*3/*3 individuals. Pharmacogenet Genomics. 24(8):407-8, 2014.
- Kwon SH, Ma SX, Lee SY, Jang CG. Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells. Neurochem Int. 74:53-64, 2014.
- Nguyen TL, Kwon SH, Hong SI, Ma SX, Jung YH, Hwang JY, Kim HC, Lee SY, Jang CG. Transient receptor potential vanilloid type 1 channel may modulate opioid reward. Neuropsychopharmacology. 39(10):2414-22, 2014.
- Kwon SH, Ma SX, Hong SI, Kim SY, Lee SY, Jang CG. Eucommia ulmoides Oliv. bark. attenuates 6-hydroxydopamine-induced neuronal cell death through inhibition of oxidative stress in SH-SY5Y cells. J Ethnopharmacol. 152(1):173-82, 2014.
- Choi CI, Bae JW, Lee YJ, Lee HI, Jang CG, Lee SY. Effects of CYP2C19 genetic polymorphisms on atomoxetine pharmacokinetics. J Clin Psychopharmacol. 34(1):139-42, 2014.
- Lee HI, Bae JW, Choi CI, Lee YJ, Byeon JY, Jang CG, Lee SY. Strongly increased exposure of meloxicam in CYP2C9*3/*3 individuals. Pharmacogenet Genomics. 24(2):113-7, 2014.
- Kwon SH, Ma SX, Joo HJ, Lee SY, Jang CG. Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice. Biomol Ther 21(6):462-9, 2013.
- Jung YH, Ha RR, Kwon SH, Hong SI, Lee KH, Kim SY, Lee SY, Jang CG. Anxiolytic effects of Julibroside C1 isolated from Albizzia julibrissin in mice. Prog Neuropsychopharmacol Biol Psychiatry. 44:184-92, 2013.
- Lee SY, You IJ, Kim MJ, Kwon SH, Hong SI, Kim JH, Jang MH, Oh SM, Chung KH, Lee SY, Jang CG. The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models. Pharmacol Biochem Behav. 105:98-104, 2013.
- Choi CI, Bae JW, Keum SK, Lee YJ, Lee HI, Jang CG, Lee SY. Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine. Xenobiotica. 43(7):636-40, 2013.
- Choi CI, Park JI, Lee HI, Lee YJ, Jang CG, Bae JW, Lee SY. Determination of tolperisone in human plasma by liquid chromatography/tandem mass spectrometry for clinical application. J Chromatogr B Analyt Technol Biomed Life Sci. 911:59-63, 2012.
- Choi CI, Lee HI, Bae JW, Lee YJ, Byeon JY, Jang CG, Lee SY. Determination of
tamsulosin in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 909:65-9, 2012. - Jung YH, Kwon SH, Hong SI, Lee SO, Kim SY, Lee SY, Jang CG. 5-HT(1A) receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia. Pharmacol Biochem Behav. 103(2):367-72, 2012.
- Hong SI, Kwon SH, Kim MJ, Ma SX, Kwon JW, Choi SM, Choi SI, Kim SY, Lee SY, Jang CG. Anxiolytic-Like Effects of Chrysanthemum indicum Aqueous Extract in Mice: Possible Involvement of GABAA Receptors and 5-HT1A Receptors. Biomol Ther 20(4):413-7, 2012.
- Kwon SH, Kim MJ, Ma SX, You IJ, Hwang JY, Oh JH, Kim SY, Kim HC, Lee SY, Jang CG. Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells. J Ethnopharmacol. 142(2):337-45, 2012.
- Bae JW, Choi CI, Lee HI, Lee YJ, Jang CG, Lee SY. Effects of CYP2C9*1/*3 and *1/*13 on the pharmacokinetics of losartan and its active metabolite E-3174. Int J Clin Pharmacol Ther. 50(9):683-9, 2012.
- Choi CI, Bae JW, Jang CG, Lee SY. Tamsulosin exposure is significantly increased by the CYP2D6*10/*10 genotype. J Clin Pharmacol. 52(12):1934-8, 2012.
- Choi CI, Bae JW, Lee HI, Jang CG, Sohn UD, Lee SY. Determination of atomoxetine metabolites in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 885-886:103-8, 2012.
- Kwon SH, Hong SI, Jung YH, Kim MJ, Kim SY, Kim HC, Lee SY, Jang CG. Lonicera japonica THUNB. protects 6-hydroxydopamine-induced neurotoxicity by inhibiting activation of MAPKs, PI3K/Akt, and NF-κB in SH-SY5Y cells. Food Chem Toxicol. 50(3-4):797-807, 2012.
- Choi CI, Lee YJ, Lee HI, Kim BH, Kim MJ, Jang CG, Bae JW, Lee SY. Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin. Xenobiotica. 42(5):496-501, 2012.
- You IJ, Jung YH, Kim MJ, Kwon SH, Hong SI, Lee SY, Jang CG. Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT₁A, GABA(A), and NMDA receptors. Neuropharmacology. 62(2):1034-43, 2012.
- Choi CI, Kim MJ, Chung EK, Lee HI, Jang CG, Bae JW, Lee SY. CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of irbesartan in healthy Korean subjects. Eur J Clin Pharmacol. 68(2):149-54, 2012.
- Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD. Characteristics of 5-hydroxytryptamine receptors involved in contraction of feline ileal longitudinal smooth muscle. Korean J Physiol Pharmacol. 15(5), 267, 2011.
- Yan XM, Joo MJ, Lim JC, Whang WK, Sim SS, Im C, Kim HR, Lee SY, Kim IK, Sohn UD. The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression. Arch Pharm Res. 34(9), 1527, 2011.
- Bae JW, Choi CI, Kim MJ, Oh DH, Keum SK, Park JI, Kim BH, Bang HK, Oh SG, Kang BS, Park HJ, Kim HD, Ha JH, Shin HJ, Kim YH, Na HS, Chung MW, Jang CG, Lee SY. Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics. Acta Pharmacol Sin. 32(10), 1303, 2011.
- Choi CI, Kim MJ, Jang CG, Park YS, Bae JW, Lee SY. Effects of the CYP2C9*1/*13 genotype on the pharmacokinetics of lornoxicam. Basic Clin Pharmacol Toxicol. 109(6), 476, 2011.
- Bae JW, Choi CI, Jang CG, Lee SY. Simultaneous determination of sibutramine and its active metabolites in human plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomed Chromatogr. 25(11), 1181. 2011.
- Bae JW, Jang CG, Lee SY. Effects of clopidogrel on the pharmacokinetics of sibutramine and its active metabolites. J Clin Pharmacol. 51(12), 1704, 2011.
- Bae JW, Choi CI, Park SH, Jang CG, Lee SY. Analytical LC-MS/MS Method for Ezetimibe and Its Application for Pharmacokinetic Study. J. Liquid Chromatogr. Related Tech. 2011 in press.
- Lee YH, Kim MJ, Choi CI, Bae JW, Jang CG, Lee SY. Retrospective study on antihyperlipidemic efficacy and safety of simvastatin, ezetimibe and their combination in Korean adults. Arch Pharm Res. 34, 1331, 2011
- Tian YH, Hwan Kim S, Lee SY, Jang CG. Lactational and postnatal exposure to polychlorinated biphenyls induces sex-specific anxiolytic behavior and cognitive deficit in mice offspring. Synapse. 65, 1032, 2011.
- Bae JW, Choi CI, Jang CG, Lee SY. Effects of CYP2C9*1/*13 on the pharmacokinetics and pharmacodynamics of meloxicam. Br J Clin Pharmacol. 71, 550, 2011
- Lee KW, Kim HC, Lee SY, Jang CG. Methamphetamine-sensitized mice are accompanied by memory impairment and reduction of N-methyl-d-aspartate receptor ligand binding in the prefrontal cortex and hippocampus. Neuroscience. 178, 101, 2011
- Kwon SH, Kim JA, Hong SI, Jung YH, Kim HC, Lee SY, Jang CG. Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells. Neurochem Int. 58, 533, 2011
- Kwon SH, Hong SI, Kim JA, Jung YH, Kim SY, Kim HC, Lee SY, Jang CG. The neuroprotective effects of Lonicera japonica THUNB. against hydrogen peroxide-induced apoptosis via phosphorylation of MAPKs and PI3K/Akt in SH-SY5Y cells. Food Chem Toxicol. 49, 1011, 2011
- Park JI, Choi CI, Jeon KJ, Bae JW, Jang CG, Lee SY. Association between ABCC2-24C>T 30. polymorphism and the pharmacokinetics of fexofenadine. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.
- Park JI, Choi CI, Bae JW, Jang CG, Lee SY. CYP2C9*3 allele markedly affects the pharmacokinetics and pharmacodynamics of meloxicam. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.
- Park JI, Choi CI, Bae JW, Jang CG, Lee SY. Effects of CYP2C9*13 allele on the pharmacokinetics of irbesartan. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.
- Keum SK, Choi CI, Bae JW, Jang CG, Lee SY. CYP2C9 genotype and dose optimization of celecoxib, a selective COX-2 inhibitor, in healthy Koreans. Clin. Pharmacol. Ther. 89, S45, 2011.
- Park JI, Choi CI, Bae JW, Jang CG, Lee SY. Effects of CYP2D6*10/*10 genotype on the pharmacokinetics of atomoxetine and its metabolites. Basic Clin. Pharmacol. Toxicol. 109(S1), 64, 2011.
- Oh DH, Bae JW, Choi CI, Jang CG, Lee SY. Effects of clopidogrel, CYP2B6 and CYP2C19 inhibitors, on the pharmacokinetics of sibutramine and its active metabolites. Clin. Pharmacol. Ther. 89, S19, 2011.
- Choi CI, Bae JW, Jang CG, Lee SY. Dose adjustment of atomoxetine based on CYP2D6 genotype in healthy Koreans. Clin. Pharmacol. Ther. 89, S45, 2011.
- Nguyen TL, Tian YH, You IJ, Lee SY, Jang CG. Modafinil-induced conditioned place preference via dopaminergic system in mice. Synapse. 65, 733, 2011
- Kwon SH, Lee HK, Kim JA, Hong SI, Kim SY, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG. Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice. Neurosci Lett. 487, 123, 2011
- Bae JW, Choi CI, Lee JH, Jang CG, Chung MW, Lee SY. Effects of UDP-glucuronosyltransferase polymorphisms on the pharmacokinetics of ezetimibe in healthy subjects. Eur J Clin Pharmacol. 67, 39, 2011
수행과제
- 한국인 CYP450약물대사효소의 약물유전체적 특성 연구 (한국연구재단)
연구부문
- 약물유전체학 (Pharmacogenomics)
심혈관계약리학 (Cardiovascular Pharmacology)
신경약리학 (Neuropharmacology)
Drug metabolism & Pharmacokinetics - 약물유전체연구(Pharmacogenomics), 중추신경계약리(Neuropharmacology), 심혈관계약리(Cardiovascular Pharmacology)에 대하여 주로 연구 하고 있다. 약물유전체연구에서는 맞춤약물, 맞춤요법 및 진단용 microarray chip개발을 목표로 약물대사효소, 약물수송자 및 수용체 유전자의 다형성(Polymorphism)이 약물의 치료작용 및 부작용에 미치는 영향을 연구하며, 중추신경계약리에서는 신경전달물질의 작용기전 연구, 퇴행성질환의 발생기전과 치료약물 개발, 중추신경계약물들의 습관성·의존성 기전연구, 행동약리 등을 연구하고, 심혈관계약리에서는 고혈압의 발생기전과 조절에 대하여 연구하고 있다.
- 그외 여러약물들의 약효/약리평가, 생동성평가, PK평가 등을 수행한다.
경피제제(Patch제)의 약효평가
진통/소염/해열/혈소판응집억제제의 약효/약리 평가
관절염치료제의 약효/약리 평가
고혈압치료제의 약효/약리 평가
당뇨병치료제의 약효/약리 평가
고지혈증치료제의 약효/약리 평가
간세포보호제의 약효/약리 평가
위장관/혈관/기관지 평활근에 작용하는 약물 약효/약리 평가
행동약리 평가
일반약리 평가
생물학적동등성 평가
등록된 연구원이 없습니다.