JH Yang, TY Song, C Jo, J Park, HY Lee, I Song, S Hong, KY Jung, J Kim, JW Han, HD Youn, EJ Cho. Differential regulation of histone chaperone HIRA by a phosphorylation switch. Exp Mol Med. 2016 12;48:e252.
IY Hwang, S Kwak, S Lee, H Kim, SE Lee, JH Kim, YA Kim, YK Jeon, DH Chung, S Park, H Jang, EJ Cho, HD Youn. Psat1-dependent fluctuations in α-Ketoglutarate affect the timing of ESC differentiation. Cell Metabolism. 2016 24(3):494-501.
Shin J, Kim TW, Kim H, Kim HJ, Suh MY, Lee S, Lee HT, Kwak S, Lee SE, Lee JH, Jang H, Cho EJ, Youn HD. Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells. eLife 2016 Feb 15; 5:e10877.
Lee JH, Kang BH, Jang Hl, Kim TW, Choi J, Kwak S, Han J, Cho EJ, Youn HD. AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage. 2015 Nucleic Acids Research 43(9); 4505-16.
Park EK, Lee JC, Park JW, Bang SY, Yi SA, Kim BK, Park JH, Kwon SH, You JS, Nam SW, Cho EJ, Han JW. Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53. Cell Death & Disease 2015 5; 6:e1964.
Kim H, Jang H, Kim TW, Kang BH, Lee SE, Jeon YK, Chung DH, Choi J, Shin J, Cho EJ, Youn HD Core pluripotency factors directly regulate embryonic stem cell metabolism to maintain pluripotency. Stem Cells 2015 33(9); 2699-2711.
JH Seol, TY Song, SE Oh, C Jo, A Choi, B Kim, J Park, S Hong, I Song, KY Jung, JH Yang, H Park, JH Ahn, JW Han, EJ Cho. Identification of small molecules that inhibit the histone chaperone Asf1 and its chromatin function. BMB report 2015 48(12); 685-690.
J Choi, H Jang, JH Lee, H Kim, ST Kim, E Cho, HD Youn. Modulation of lysine methylation in myocytes enhancer factor 2 during skeletal muscle cell differentiation. 2014 Nucleic Acids Research 42 (1); 224-234.
Y Song, JH Yang, JH Seol, HJ Kim, JW Han, HD Youn, EJ Cho. Dissecting the roles of the histone chaperones reveals the evolutionary conserved mechanism of transcription-coupled deposition of H3.3. 2013 Nucleic Acids Research 41 (10); 5199-5209.
YJ Yang, TY Song, J Park, J Lee, J Lim, Hl Jang, YN Kim, JH Yang, Y Song, A Choi, H Lee, C Jo, JW Han, ST Kim, HD Youn. EJ Cho.. Menin mediates epigenetic regulation via histone H3 lysine 9 methylation. 2013 Cell Death and Disease 4, 583.
Choi SY, Jang H, Roe JS, Kim ST, Cho EJ, Youn HD. Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress. Nucleic Acids Research 2013 1;41(4):2180-2190.
수행과제
근육소실과정에서 근육량조절에 미치는 크로마틴의 영향 연구 (한국연구재단)
Long non-coding RNA에 의한 헤테로크로마틴 형성 기전 연구 (한국연구재단)
씨앤드씨 약물 효능평가(씨앤드씨 약물의 Chromatin-IP를 통한 효능평가)
에피제네틱 코드의 새로운 대사적 조절 연구 (한국연구재단)
연구부문
Non-coding RNAs, Transcriptome analysis
Chromatin dynamics and epigenetic regulation of gene expression, Cell fate determination & Cell differentiation
Cancer epigenetics, Epigenetic mechanism of tumorigenesis
Molecular understanding of tumor suppressor/oncogene function & cancer biology
