교수/연구실 소개

>대학소개 >교수/연구실 소개

전임교수

조 동 규Dong Gyu Jo

전공세포생리학, 약물신호전달학
사무실No. 530418
031-290-7782
연구실No. 530412
031-290-7776
e-mailjodg@skku.edu

이메일jodg@skku.edu
홈페이지ageomics.org
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학력/경력

최근 연구업적

selected from 2014-present (https://www.ncbi.nlm.nih.gov/pubmed/?term=jo+dg)
Arumugam TV, Baik SH, Balaganapathy P, Sobey CG, Mattson MP, Jo DG* (2018) Notch signaling and neuronal death in stroke. Prog. Neurobiol. 165, 103-116.
Choi BY, Choi Y, Park JS, Bahn G, Park JS, Cho Y, Baek SH, Kim HG, Kang YM, Park JH, Jo DG* (2018) Inhibition of Notch1 Induces Population and Suppressive Activity of Regulatory T Cell in Inflammatory Arthritis. Theranostics 8, 4795-4804.
Balaganapathy P, Baik SH, Mallilankaraman K, Sobey CG, Arumugam TV, Jo DG* (2018) Interplay Between the Notch and p53 Promotes Neuronal Cell Death in Ischemic Stroke. J Cereb Blood Flow Metab. 38, 1781-1795.
Beck SH, Park SJ, Jeong JI, Kim SH, Han J, Kyung JW, Baik SH, Choi Y, Choi BY, Park J, Bahn G, Shin JH, Jo DS, Lee JY, Jang CG, Arumugam TV, Han JW, Koh JY, Cho DH, Jo DG* (2017) Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition and Cognitive Impairment in Alzheimer’s Disease Model. J. Neurosci. 37, 5099-5110.
Song J, Yun UJ, Yang S, Seo CR, Baik SH, Choi Y, Jang YJ, Jeong JI, Kim S, Kwon SM, Kim BJ, Park KW*, Jo DG* (2016) Notch1 insufficiency decreases lipid accumulation by induction of oxidative genes. Sci. Rep. 20;6:19377.
Kim MJ, Park JS, Lee SJ, Jang J, Park JS, Back SH, Bhan G, Park JH, Kwon IC, Kim K*, Jo DG* (2015) Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy. J. Control. Release 216, 140-148.
Baik SH, Fane M, Park JH, Cheng YL, Park JS, Choi Y, Chai BH, Yun UJ, Jeong JI, Jang YJ, Bahn G, Back SH, Park JS, Sobey CG, Uchida T, Park JH, Tang SC, Arumugam TV, Jo DG* (2015) Pin1 Mediates Cell Death by Modulating Notch1 Stability in Ischemic Stroke. Ann. Neurol. 77, 504-515.
Cheng YL, Choi Y, Sobey CG, Arumugam TV, Jo DG* (2015) Emerging roles of the γ-secretase-notch axis in inflammation. Pharmacol. Ther. 147, 80-90.
Park JS, Kim SH, Kim K, Jin CH, Choi KY, Jang J, Gwon AR, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Chae SY, Lee KC, Arumugam TV, Mattson MP, Park JH, Jo DG* (2015) Inhibition of notch signalling ameliorates experimental rheumatoid arthritis. Ann. Rheum. Dis.74, 267-274. (Recommended in F1000)
Heo R, Park JS, Jang HJ, Kim SH, Shin JM, Suh YD, Jeong JH, Park JH*, Jo DG* (2014) Nanoparticles Bearing γ-Secretase Inhibitor: In Vivo Therapeutic Effects on Rheumatoid Arthritis. J. Control. Release 192, 295-300.
Shin JM, Kim SH, Thambi T, You DG, Jeon J, Lee JO, Chung BY, Park JH*, Jo DG* (2014) A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis. Chem. Commun. (Camb) 50, 7632-7635.
Cheng YL, Park JS, Manzanero S, Baik S, Gelderblom M, Magnus T, Sobey CG, Arumugam TV*, Jo DG* (2014) Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiol. Dis. 62, 286-295.

수행과제

3xTg, 5FXAD, PS19 mouse를 이용한 행동실험평가 및 뇌 조직병리학적 분석 시험
APP/PS1,5FXAD mouse를 이용한 행동실험평가 및 뇌 조직병리학적 분석 시험
β-secretase의 통합적 조절 네트워크에 기반한 Alzheimer 치매 제어 연구 (한국연구재단)
알츠하이머 치매와 허혈성 뇌졸중에서 Notch의 신경세포사멸 조절 연구 (한국보건산업진흥원)
신규 화합물 라밀린의 항치매 활성기전 규명
양극해 해양생물 유래 생리활성물질 검색을 통한 신규 항치매 물질발굴 (해양수산부)

연구부문

Molecular mechanisms of neurodegenerative diseases (Alzheimer’s disease, ischemic stroke, Parkinson'd disease) and brain aging.
Molecular mechanisms of diabetes and rheumatoid arthritis.
Identification of therapeutic targets of these diseases.
Development of new screening strategy and screening to discover new candidates of drugs

성균관대학교 약학대학

skku school of pharmacy

교수/연구실 소개

조 동 규Dong Gyu Jo

학력

주요경력

최근 연구업적

수행과제

연구부문