교수/연구실 소개
>대학소개 >교수/연구실 소개
김 기 현Ki Hyun Kim
- 전공천연물약품화학/생약학
- 사무실No. 530728
031-290-7700 - 연구실No. 530730
031-290-7765 - e-mailkhkim83@skku.edu
학력
- 2001-2005 : 성균관대학교 약학대학 약학부 약학사
- 2005-2007 : 성균관대학교 약학대학 제약학과 약학석사
- 2007-2011 : 성균관대학교 약학대학 약학과 약학박사
주요경력
- 2014.03 - 2018.02 : 성균관대학교 약학대학 조교수
- 2018.03 - 2023.02 : 성균관대학교 약학대학 부교수
- 2023.03 - 현재 : 성균관대학교 약학대학 교수
- 2012.03 -2012.10 : Havard University, Postdoctoral Research Fellow
- 2012.10 - 2014.02 : Harvard Medical School, Postdoctoral Research Fellow
- 2014.05 - 현재 : Archives of Pharmacal Research, Associate Editor
- 2015.03 - 현재 : Journal of Ginseng Research, Associate Editor
- 2015.03 - 현재 : 한국생약학회, 총무 간사 및 학술 간사
- 2016.08 - 현재 : 식품의약품 안전처, 중앙약사심의위원회 전문가
- 2017.05 - 현재 : Bioorganic Chemistry, Editorial Board Member
- 2018.10 - 현재 : Separations, Journal Editorial Board
- 2018.12 - 현재 : Plants, Journal Editorial Board
- 2019.01 - 현재 : Mycobiology, Associate Editor
- 2019.03 - 현재 : Natural Product Sciences, Associate Editor
최근 연구업적
- Kim, Sil; Yu, Jae Sik; Lee, Ji Young; Choi, Sang Un; Lee, Jeongmi; Kim, Ki Hyun.* Cytotoxic Withanolides from the Roots of Indian Ginseng (Withania somnifera). J. Nat. Prod. 2019, in press.
- Kim, Da Wan; Baik, Sangyul; Min, Hyeongho; Chun, Sungwoo; Lee, Heon Joon; Kim, Ki Hyun; Lee, Jun Young; Pang, Changhyun.* Highly permeable skin patch with conductive hierarchical architectures inspired by amphibians and octopi for omnidirectionally enhanced wet adhesion. Adv. Funct. Mater. 2019, 29, 1807614.
- Rischera, Maja; # Lee, Seoung Rak;# Eom, Hee Jeong; Park, Hyun Bong; Vollmers, John; Kaster, Anne-Kristin; Shin, Yern-Hyerk; Oh, Dong-Chan; Kim, Ki Hyun;* Beemelmanns, Christine.* Spirocyclic cladosporicin A and cladosporiumins I and J from a Hydractinia-associated Cladosporium sphaerospermum SW67. Org. Chem. Front. 2019, in press.
- Lee, Seoung Rak; Seok, Soonja; Ryoo, Rhim; Choi, Sang Un; Kim, Ki Hyun.* Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom Podostroma cornu-damae. J. Nat. Prod. 2019, 82, 122-128.
- Lee, Seoung Rak; Küfner, Michelle; Park, Minji; Jung, Won Hee; Choi, Sang Un; Beemelmanns, Christine; Kim, Ki Hyun.* Beauvetetraones A-C, phomaligadione-derived polyketide dimers from the entomopathogenic fungus, Beauveria bassiana. Org. Chem. Front. 2019, 6, 162-166.
- Strandwitz, Philip;1 Kim, Ki Hyun;1 Terekhova, Darya; Liu, Joanne K.; Sharma, Anukriti; Levering, Jennifer; McDonald, Daniel; Dietrich, David; Ramadhar, Timothy R.; Lekbua, Asama; Mroue, Nader; Liston, Conor; Stewart, Eric J.; Dubin, Marc J.; Zengler, Karsten; Knight, Rob; Gilbert, Jack A.; Clardy, Jon; Lewis, Kim. GABA Modulating Bacteria of the Human Gut Microbiota. Nat. Microbiol. 2019, 4, 396–403.
- Lee, Seoung Rak; Park, Yong Joo; Han, Yu Bin; Lee, Joo Chan; Lee, Seulah; Park, Hyun-Ju; Lee, Hae-Jeung;* Kim, Ki Hyun.* Isoamericanoic Acid B from Acer tegmentosum as a Potential Phytoestrogen. Nutrients 2018, 10, 1915.
- Lee, Seoung Rak; Park, Hyun Bong; Kim, Ki Hyun.* Highly sensitive, simple, and cost/time-effective method to determine the absolute configuration of a secondary alcohol using competing enantioselective acylation coupled with LC/MS. Anal. Chem. 2018, 90, 13212-13216.
- Lee, Seulah;† Lee, Seul;† Roh, Hyun-Soo; Song, Seong-Soo; Ryoo, Rhim; Pang, Changhyun; Baek, Kwan-Hyuck;* Kim, Ki Hyun.* Cytotoxic Constituents from the Sclerotia of Poria cocos against Human Lung Adenocarcinoma Cells by Inducing Mitochondrial Apoptosis. Cells 2018, 7, 116.
- Kang, Hee Rae; Yun, Hyung Sik; Lee, Tae Kyoung; Lee, Seulah; Kim, Seon-Hee; Moon, Eunjung; Park, Ki-Moon; Kim, Ki Hyun.* Chemical Characterization of Novel Natural Products from the Roots of Asian Rice (Oryza sativa) that Control Adipocyte and Osteoblast Differentiation. J. Agric. Food Chem. 2018, 66, 2677-2684.
- Shin, Seung Ho; 1 Lee, Seoung Rak; 1 Lee, Eunjung; Kim, Ki Hyun;* Byun, Sanguine.* Caffeic Acid Phenethyl Ester from the Twigs of Cinnamomum cassia Inhibits Malignant Cell Transformation by Inducing c‑Fos Degradation. J. Nat. Prod. 2017, 80, 2124–2130.
- Wyche, Thomas P.; Ruzzini, Antonio C.; Beemelmanns, Christine; Kim, Ki Hyun; Klassen, Jonathan L.; Cao, Shugeng; Poulsen, Michael; Bugni, Tim S.; Currie, Cameron R.; Clardy, Jon. Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Org. Lett. 2017, 19, 1772–1775.
- Beemelmanns, Christine;% Ramadhar, Timothy R.;% Kim, Ki Hyun;% Klassen, Jonathan L.; Cao, Shugeng; Wyche, Thomas P.; Hou, Yanpeng; Poulsen, Michael; Bugni, Tim S.; Currie, Cameron R.; Clardy, Jon. Macrotermycins A−D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Org. Lett. 2017, 19, 1000–1003. %contributed equally
- Segev, Einat; Wyche, Thomas P.; Kim, Ki Hyun; Petersen, Jörn; Ellebrandt, Claire; Vlamakis, Hera; Barteneva, Natasha; Paulson, Joseph N.; Chai, Liraz; Clardy, Jon; Kolter, Roberto. Dynamic metabolic exchange governs a marine algal-bacterial interaction. eLife 2016, 5, e17473.
- Kang, Hee Rae; Lee, Dahae; Benndorf, René; Jung, Won Hee; Beemelmanns, Christine; Kang, Ki Sung; Kim, Ki Hyun.* Termisoflavones A–C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1. J. Nat. Prod. 2016, 79, 3072−3078.
- Eom, Hee Jeong; Lee, Dahae; Lee, Seulah; Noh, Hyung Jun; Hyun, Jae Wook; Yi, Pyoung Ho; Kang, Ki Sung; Kim, Ki Hyun.* Flavonoids and a Limonoid from the Fruits of Citrus unshiu and their Biological Activity. J. Agric. Food Chem. 2016, 64, 7171–7178.
- Lee, Seoung Rak; Park, Jun Yeon, Yu, Jae Sik, Lee, Sung Ok; Ryu, Ja-Young; Choi, Sang-Zin; Kang, Ki Sung; Yamabe, Noriko;* Kim, Ki Hyun.* Odisolane, a Novel Oxolane Derivative and Antiangiogenic Constituents from the Fruits of Mulberry (Morus alba L.). J. Agric. Food Chem. 2016, 64, 3804−3809.
- Kim, Ki Hyun; Park, Yong Joo; Chung, Kyu Hyuck; Yip, M. L. Richard; Clardy, Jon; Senger, Donald; Cao, Shugeng. Iridoid Glycosides from Barleria lupulina. J. Nat. Prod. 2015, 78, 320–324.
- Kim, Ki Hyun; Woo, Kyeong Wan; Moon, Eunjung; Choi, Sang Un; Kim, Sun Yeou; Choi, Sang Zin; Son, Mi Won; Lee, Kang Ro. Identification of antitumor lignans from the seeds of morning glory (Pharbitis nil). J. Agric. Food Chem. 2014, 62, 7746−7752.
- Kim, Ki Hyun; Ramadhar, Timothy R.; Beemelmanns, Christine; Cao, Shugeng; Poulsen, Michael; Currie, Cameron R.; Clardy, Jon. Natalamycin A, an ansamycin from a termite-associated Streptomyces sp. Chem. Sci. 2014, 5, 4333–4338.
수행과제
- 유근피의 성분분리 연구
- JAK3 Inhibition 활성 물질을 활용한 발모제 개발 연구
- 흰개미 공생 미생물로부터 신규 생리활성 물질 탐색과 항균 및 항진균 선도물질 개발 연구
- 갓그물버섯의 항암활성 연구와 신규 천연 항암제 발굴 및 기전 연구
- 약물 내 acanthoside D 함량 분석
- 다양한 골격을 가진 천연물 라이브러리 제공
- 뱀껍질광대버섯으로부터 신규 항암활성 성분 연구
- 시료의 추출 및 농축
- 국내 야생 약용 버섯으로부터 위점막 보호 활성물질의 검색 및 위염치료제 소재 개발
- 뽕나무버섯부치로부터 위점막 보호 활성 물질 검색 및 위염치료제 소재 개발
연구부문
- Isolation and structure of natural products
- Chemical biology of natural products