학력

최근 연구업적

1.     Sang Ah Yi, Liang Sun, Yi Rao, Alban Ordureau, Jason S. Lewis, Heeseon An*, Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1 in the mevalonate pathway. Journal of Biological Chemistry, Accepted (2025)

2.     Sang Ah Yi, Daseul Cho, Sujin Kim, Hyunjin Kim, Myung Kyung Choi, Hee Seong Choi, Sukjin Shin, Sujin Yun, Ahjin Lim, Jae Kyun Jeong, Da Eun Yoon, Hye Ji Cha, Kyoungmi Kim, Jeung-Whan Han*, Hyun-Soo Cho*, Jeonghee Cho*, Functional loss of MIG6 promotes glioblastoma tumorigenesis by aberrant activation of EGF receptor. Molecular Oncology, 19(3):937-953 (2025)

3.     Sang Ah Yi, Thanapat Pongkulapa, Sarah Nevins, Li Ling Goldston, Meizi Chen, Ki-Bum Lee*, Developing miR-133a Zipper Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation. Advanced Healthcare Materials, 13(22):e2400654 (2024)

4.     Sang Ah Yi, Sara Sepic, Brenda A Schulman, Alban Ordureau, Heeseon An*, mTORC1-CTLH E3 Ligase Regulates the Degradation of HMG-CoA Synthase 1 through the Pro/N-Degron Pathway. Molecular Cell, 84(11):2166-2184 (2024)

5.     Nam Hyeong Kim, Sudong Chae, Sang Ah Yi, (Co-first author) Deok Hyang Sa, Seungbae Oh, Eun Sung Kang, Suhyeon Kim, Kyung Hwan Choi, Jaecheol Lee*, Jae-Young Choi*, Yong Ho Kim*, Peptide-Assembled Single-Chain Atomic Crystal Enhances Pluripotent Stem Cell Differentiation to Neurons. Nano Letters, 23(15):6859-6867 (2023)

6.     Jae Sung Noh, Jae Kyun Jeong, Jeung-Whan Han*, Sang Ah Yi*, Rg3 and Rh2 ginsenosides suppress embryoid body formation by inhibiting the epithelial-mesenchymal transition. Archives of Pharmacal Research, 45(7):494-505 (2022)

7.     Sang Ah Yi*, Ye Ji Jeon, Min Gyu Lee, Ki Hong Nam, Sora Ann, Jaecheol Lee*, Jeung-Whan Han*, S6K1 Controls Adiponectin Expression by Inducing A Transcriptional Switch: BMAL1-to-EZH2. Experimental & Molecular Medicine, 54(3):324-333 (2022)

8.     Ye Ji Jeon, Sang Ah Yi, (Co-first author) Jaecheol Lee*, Jeung-Whan Han*, Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway. Biochemical and Biophysical Research Communications, 594:101-108 (2022)

9.     Sang Ah Yi, Yixiao Zhang, Christopher Rathnam, Thanapat Pongkulapa, & Ki-Bum Lee*, Bioengineering Approaches for the Advancement of Organoid Research. Advanced Materials, 33(45): e2007949 (2021)

10.    Sang Ah Yi, Ki Hong Nam, Min Gyu Lee, Hwamok Oh, Jae Sung Noh, Jae Kyun Jeong, Sangwoo Kwak, Ye Ji Jeon, So Hee Kwon, Jaecheol Lee, Jeung-Whan Han*, Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as A PRC2 Modulator. Molecules, 26(18):5665 (2021)

11.  Su Cheol Baek, Sang Ah Yi, (Co-first author) Bum Soo Lee, Jae Sik Yu, Jin-Chul Kim, Changhyun Pang, Tae Su Jang, Jaecheol Lee*, & Ki Hyun Kim*, Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius). Biomedicines, 9(1):E91 (2021)

12.  Sook In Chae, Sang Ah Yi, (Co-first author) Ki Hong Nam, Kyoung Jin Park, Jihye Yun, Ki Hyun Kim, Jaecheol Lee, & Jeung-Whan Han*, Morolic Acid 3-O-Caffeate Inhibits Adipogenesis by Regulating Epigenetic Gene Expression. Molecules, 25(24):5910 (2020)

13.  Sang Ah Yi*, Ki Hong Nam, Jihye Yun, Dongmin Gim, Daeho Joe, Yong Ho Kim, Han-Joo Kim, Jeung-Whan Han, & Jaecheol Lee*, Infection of brain organoids and 2D cortical neurons with SARS-CoV-2 pseudovirus. Viruses, 12(9):1004 (2020)

14.  Ki Hong Nam, Sang Ah Yi, (Co-first author) Hyun Ji Jang, Jeung-Whan Han, & Jaecheol Lee*, In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid. Archives of Pharmacal Research, 43(9):877-889 (2020)

15.  Sang Ah Yi, Go Woon Kim, Jung Yoo, Jeung-Whan Han* & So Hee Kwon*, HP1γ sensitizes cervical cancer cells to cisplatin through the suppression of UBE2L3. International Journal of Molecular Sciences, 21(17):5976 (2020)

16.  Sang Ah Yi, Dong Hoon Lee, Go Woon Kim, Hyun-Wook Ryu, Jong Woo Park, Jaecheol Lee, Jihoon Han, Jee Hun Park, Hwamok Oh, Jieun Lee, Junjeong Choi, Hyun-Soo Kim, Hyeok Gu Kang, Da-Hyun Kim, Kyung-Hee Chun, Jueng Soo You, Jeung-Whan Han* & So Hee Kwon*, HPV-Mediated Nuclear Export of HP1γ Drives Cervical Tumorigenesis by Downregulation of p53. Cell Death & Differentiation, 27(9):2537-2551 (2020)

17.  Sang Ah Yi, Jieun Lee, Sun Kyu Park, Jeom Yong Kim, Jong Woo Park, Min Gyu Lee, Ki Hong Nam, Jee Hun Park, Hwamok Oh, Saetbyul Kim, Jihoon Han, Bo Kyung Kim, Dong-Gyu Jo & Jeung-Whan Han*, Fermented ginseng extract, BST204, disturbs adipogenesis of mesenchymal stem cells through inhibition of S6K1 signaling. Journal of Ginseng Research, 44(1):58-66 (2020)

18.  Sang Ah Yi, Ki Hong Nam, Sil Kim, Hae Min So, Rhim Ryoo, Jeung-Whan Han, Ki Hyun Kim*, & Jaecheol Lee*, Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis. Genes, 11(1):18 (2019)

19.  Su Cheol Baek, Ki Hong Nam, Sang Ah Yi, (Co-first author) Mun Seok Jo, Kwang Ho Lee, Yong Hoon Lee, Jaecheol Lee*, & Ki Hyun Kim*, Anti-adipogenic Effect of β-Carboline Alkaloids from Garlic (Allium sativum). Foods, 8(12):673 (2019)

20.  Saetbyul Kim, Jong Woo Park, Min Gyu Lee, Ki Hong Nam, Jee Hun Park, Hwamok Oh, Jieun Lee, Jihoon Han, Sang Ah Yi*, (Co-corresponding author) & Jeung-Whan Han*, Reversine Promotes Browning of White Adipocytes by Suppressing miR-133a. Journal of Cellular Physiology, 234(4):3800-3813 (2019)

21.  Ki Hong Nam, Sang Ah Yi, (Co-first author) Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee, & Jeung-Whan Han*, Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer. BMC Cancer, 19(1):773 (2019)

22.  Ki Hong Nam, Sang Ah Yi, (Co-first author) Jaecheol Lee, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Jong Woo Park*, & Jeung-Whan Han*, Eudesmin impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Biochemical and Biophysical Research Communications, 505(4):1148-1153 (2018)

23.  Sang Ah Yi, Jieun Lee, Jong Woo Park, Jihoon Han, Min Gyu Lee, Ki Hong Nam, Jee Hun Park, Hwamok Oh, Sung Jin Ahn, Saetbyul Kim, So Hee Kwon, Dong‐Gyu Jo & Jeung‐Whan Han*, S6K1 controls epigenetic plasticity for the expression of pancreatic α/β cell marker genes. Journal of Cellular Biochemistry, 119(8):6674-6683 (2018)

24.  Sang Ah Yi, Jihoon Han & Jeung-Whan Han*, Epigenetic role of nuclear S6K1 in early adipogenesis. BMB Reports, 49(8):401-402 (2016)

25.  Sang Ah Yi, Sung Hee Um, Jaecheol Lee, Ji Hee Yoo, So Young Bang, Eun Kyung Park, Min Gyu Lee, Ki Hong Nam, Ye Ji Jeon, Jong Woo Park, Jueng Soo You, Sang-Jin Lee, Gyu-Un Bae, Jong Won Rhie, Sara C. Kozma, George Thomas* & Jeung-Whan Han*, S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis. Molecular Cell, 62(3):443-452 (2016)

26.  Sang Ah Yi, Hyun‑Wook Ryu, Dong Hoon Lee, Jeung‑Whan Han & So Hee Kwon*, HP1β suppresses metastasis of human cancer cells by decreasing the expression and activation of MMP2. International Journal of Oncology, 45(6):2541-2548 (2014)

27.  Munkyung Kim, Sang Ah Yi, (Co-first author) Hyunwoo Lee, So Young Bang, Eun Kyung Park, Min Gyu Lee, Ki Hong Nam, Ji Hee Yoo, Dong Hoon Lee, Hyun-Wook Ryu, So Hee Kwon & Jeung-Whan Han*, Reversine induces multipotency of lineage-committed cells through epigenetic silencing of miR-133a. Biochemical and Biophysical Research Communications, 445(1):255-262 (2014)

연구부문

• 다중오믹스 (NGS, proteomics) 기반 질환 표적분자 규명
• 데그론 태깅 (degron tagging)을 통한 표적분자치료제 개발
• 세포내 protein quality control 기전 연구
• Chemoproteomics 기반 신약 개발 연구