학력

• 2008. 05  McGIll University (Biochemistry/Pharmacology and therapeutics 전공) 이학사
• 2011. 02  서울대학교 약학대학 (물리약학) 약학석사
• 2016. 06  University of Toronto (Pharmaceutical Sciences 전공) 약학박사

최근 연구업적

• Tiep Tien Nguyen, Mai Thi Phuong, Manju Shrestha, Junhyeung Park, Pham Le Minh, Jong Oh Kim, Hyukjae Choi, Joo-Won Nam, Hu-Lin Jiang, Hyung-Sik Kim, Jee-Heon Jeong, Jun-Beom Park, Simmyung Yook**, Scalable and Uniform Fabrication of Dexamethasone-Eluting Depot-Engineered Stem Cell Spheroids as a Microtissue Construct to Target Bone Regeneration“ ACS Applied Materials & Interfaces, 2023:15(22):26373-26384
  
• Ramesh Duwa, Ram Hari Pokhrel, Asmita Banstola, Mahesh Pandit, Prakash Shrestha, Jee-Heon Jeong, Jae-Hoon Chang, Simmyung Yook**, T-cell engaging poly(lactic-co-glycolic acid) nanoparticles as a modular platform to induce a potent cytotoxic immunogenic response against PD-L1 overexpressing cancer”. Biomaterials, 2022;291:121911
• Tiep Tien Nguyen, Duc-Vinh Pham, Junhyeung Park, Cao Dai Phung, Mahesh Raj Nepal, Mahesh Pandit, Manju Shrestha, Youlim Son, Mili Joshi, Tae Cheon Jeong, Pil-Hoon Park, Dong-Young Choi, Jae-Hoon Chang, Ju-Hyun Kim, Jae-Ryong Kim, Il-Kug Kim, Chul Soon Yong, Jong Oh Kim, Jong-Hyuk Sung, Hu-Lin Jiang, Hyung-Sik Kim, Simmyung Yook**, Jee-Heon Jeong, “Engineering of hybrid spheroids of mesenchymal stem cells and drug depots for immunomodulating effect in islet xenotransplantation”. Science Advances, 2022;8(34):eabn8614
• Asmita Banstola, Mahesh Pandit, Ramesh Duwa, Jae-Hoon Chang, Simmyung Yook**, “Reactive Oxygen Species-responsive dual targeted smart nanosystem boosted cellular immunity breast cancer by promoting immune cell infiltration and immunogenic cell death”. Bioengineering & translational medicine, 2022; e10379
• Samjhana Shrestha, Asmita Banstola, Jee-Heon Jeong, Ji Hae Seo, Simmyung Yook*, “Targeting cancer stem cells: therapeutic and diagnostic strategies by the virtue of nanoparticles”, Journal of Controlled Release, 2022;348:518-536
• Nikita Katila, Ramesh Duwa, Sunil Bhurtel, Shristi Khanal, Srijan Maharjan, Jee-Heon Jeong, Sooyeon Lee, Dong-Young Choi, Simmyung Yook**, “Enhancement of blood-brain barrier penetration and the neuroprotective effect of resveratrol”. Journal of controlled release, 2022; 346: 1-19 – highlighted in cover page 
• Asmita Banstola, Kishwor Poudel, Jong Oh Kim, Jee-Heon Jeong**, Simmyung Yook**, “Recent progress in stimuli-responsive nanosystem for inducing immunogenic cell death”. Journal of Controlled Release 2021;337:505-520
• Tiep Tien Nguyen, Cao Dai Phung, Jong Oh Kim, Chul Soon Yong, Jae-Ryong Kim, Simmyung Yook**, and Jee-Heon Jeong**, “The impact of locally-delivered tacrolimus-releasing microspheres and polyethylene glycol-based islet surface modification on xenogeneic islet survival”. Journal of Controlled Release 2021;336:274-284
• Tung Thanh Pham, Phuong Le Tran, Cao Dai Phung, Hanh Thuy Nguyen, Canh Hung Nguyen, Chul Soon Yong, Jong Oh Kim, Simmyung Yook**, Jee-Heon Jeong**, “Surface-Triggered In Situ Gelation for Tunable Conformal Hydrogel Coating of Therapeutic Cells and Biomedical Devices”. Advanced Functional Materials 2021;31:2010169
• Asmita Banstola, Kishwor Poudel, Shiva Pathak, Prakash Shrestha, Jong Oh Kim, Jee-Heon Jeong.**, Simmyung Yook** “Hypoxia-Mediated ROS Amplification Triggers Mitochondria-Mediated Apoptotic Cell Death via PD-L1/ROS-Responsive, Dual-Targeted, Drug-Laden Thioketal Nanoparticles”. ACS Applied Materials & Interfaces 2021;13(19):22955-22969
• Asmita Banstola, Kishwor Poudel, Fakhrossadat Emami, Sae Kwang Ku, Jee-Heon Jeong, Jong Oh Kim**, Simmyung Yook** “Localized therapy using anti-PD-L1 anchored and NIR-responsive hollow gold nanoshell (HGNS) loaded with doxorubicin (DOX) for the treatment of locally advanced melanoma”. Nanomedicine: Nanotechnology, Biology and Medicine 2021;33:102349

• Fakhrossadat Emami, Shiva Pathak, Tiep Tien Nguyen, Prakash Shrestha, Srijan Maharjan, Jong Oh Kim, Jee-Heon Jeong**, Simmyung Yook**, “Photoimmunotherapy with cetuximab-conjugated gold nanorods reduces drug resistance in triple negative breast cancer spheroids with enhanced infiltration of tumor-associated macrophages”. Journal of Controlled Release 2021;329:645-664

연구부문

• My current research is focusing on developing bio-responsive and targeted nanoparticle platform, on designing tumor microenvironment reprogramming technology, on developing antibody drug conjugate and on developing immune-modulating bispecific nanoplatform