교수/연구실 소개
>대학소개 >교수/연구실 소개
이 강 노Kang Ro Lee
- 전공천연물약품화학
- 사무실No. 530738
031-290-7710 - 연구실No. 530739
031-290-7750 - e-mailkrlee@skku.edu
학력
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Ph.D. Bonn University, Germany
주요경력
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1983 - 1985 : 대웅제약 중앙연구소
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1989 - 1990 : 한국 과학 기술 연구원 (KIST)
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1991 - 1995 : 성균관대학교 약학대학 조교수
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1996 - 1999 : 성균관대학교 약학대학 부교수
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2000 - 현재 : 성균관대학교 약학대학 교수
최근 연구업적
- Kim,Y.S., Suh,W.S., Park,K.J., Choi,S.U. and Lee,K.R. Allimacrosides A-E, new steroidal glycosides from Allium macrostemon. Steroids, 118, 41-46 (2017.2) (2017)
- Kim,C.S., Bae,M., Oh,J., Subedi,L., Suh,W.S., Choi,S.Z., Son,M.W., Kim,S.Y., Choi,S.U., Oh,D.C. and Lee,K.R. Anti-Neurodegenerative biflavonoid glycosides from Impatiens balsamina. J. Nat. Prod., 80, 471-478 (2017.2) (2017)
- Kim,C.S., Oh,J., Subedi,L., Kim,S.Y., Choi,S.U. and Lee,K.R. Holophyllane A: atriterpenoid possessing an unprecedented B-nor-3,4-seco-17,14-friedo-lanostane architecture from Abies holophylla. Sci. Rep., 7, 43646 (2017.3) (2017)
- Park,K.J., Suh,W.S., Subedi,L., Kim,S.Y., Choi,S.U., and Lee,K.R., Secoiridoid glucosides from the Twigs of Syringa oblarata var.dilatata and their neuroprotective and cytotoxic activities. Chem. Pharm. Bull. 65(4) 359-364. (2017)
- Suh,W.S., Park,K.J., Kim,D.H., Subedi,L., Kim,S.Y., Choi,S.U. and Lee,K.R. A biphenyl derivative from the twigs of Chaenomeles speciosa. Bioorg. Chem., 72, 156-160 (2017.5) (2017)
- Kim,C.S., Oh,J., Subedi,L., Kim,S.Y., Choi,S.U. and Lee,K.R. Bioactive triterpenoids from the twigs of Chaenomelels sinensis. J. Nat. Prod., 80, 1134-1140 (2017.3) (2017)
- Woo,K.W., Park,K.J., Choi,S.Z, Son, M.W., Kim, K.H., and Lee,K.R.A new ent-Kaurane diterpene glycoside from seeds of Pharbitis nil. Chem. Nat. Compd., 53, 468-471 (2017.5) (2017)
- Cha,J.M., Suh,W.S., Lee,T.H., Subedi,L., Kim,S.Y., and Lee,K.R., Phenolic glycosides from Capsella bursa-pastoris (L.) Medik and their anti-inflammatory activity. Molecules 22(6) 1023 (2017.6) (2017)
- Lim,S.Y., Subedi,L., Shin,D.Y.,Kim,C.S., Lee,K.R. and Kim,S.Y. A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation Biomol. ther., 1-9 (2017.5) (2017)
- Suh,W.S., Kim,C.S., Subedi,L., Kim,S.Y.,Choi,S.U., Lee,K.R. Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities. J. Nat. Prod., 80, 2502-2508 (2017.8) (2017)
- Kim,C.S., Oh, J., Suh,W.S., Jang,S.W., Subedi L., Kim, S.Y., Choi,S.U. and Lee,K.R. Investigation of chemical constituents from Spiraea prunifolia var. simpliciflora and their biological activities. Phytochem. Lett., 22, 255-260 (2017.9) (2017)
- Kim,C.S., Subedi,L., Kwon,O.K., Kim,S.Y., Yeo,E.J., Choi,S.U. and Lee,K.R. Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis. Bioorg. Med. Chem. Lett., 26, 351-354 (2016)
- Kang,H.R., Lee,D., Eom,H.J., Lee,S.R., Lee,K.R., Kang,K.S. and Kim,K.H. Identification and mechanism of action of
renoprotective constituents from peat moss Sphagnum palustre in cisplatin-induced nephrotoxicity. J. Funct. Foods, 20, 358-368 (2016) - Kim, C.S., Subedi, L., Kim, S.Y., Choi, S.U., Kim, K.H., and Lee,K.R. Diterpenes from the trunk of Abies holophylla and their potential neuroprotective and anti-inflammatory activities. J. Nat. Prod. 79, 387-394 (2016)
- Cho, S., Im, H., Lee, K.Y., Chen, J., Kang, H.J., Yoon, H,J, Min, K.H., Lee, K.R. , Park, H.J., and Lee, B.J.,
Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-D-mannooctulosonate 8-phosphate synthase (HpKDO8PS) Eur. J. Med. Chem. 108, 188-202 (2016) - Kim, E.J., Yoon, Y.P., Woo, K.W., Kim, J.H., Min, S.Y., Lee, H.J., Lee, S.K. Hong, J.H., Lee,K.R., and Lee.C.J. Verticine, ebeiedine and suchengbeisine isolated from the bulbs of Fritillaria thunbergii Miq. inhibited the gene expression and production of MUC5AC mucin from human airway epithelial cells. Phytomedicine 23, 95-104 (2016)
- Woo,K.W., Suh,W.S., Subedi,L., Kim,S.Y., Kim,A. and Lee,K.R. Bioactive lignan derivatives from the stems of Firmiana simplex. Bioorg. Med. Chem. Lett., 26, 730-733 (2016)
- Suh,W.S., Subedi,L., Kim,S.Y., Choi,S.U. and Lee,K.R. Bioactive lignan constituents from the twigs of Sambucus williamsii. Bioorg. Med. Chem. Lett., 26, 1877-1880 (2016.4) (2016)
- Suh,W.S., Lee,S.R., Kim,C.S., Moon,E., KIM,S.Y., Choi,S.U., Kang,K.S., Lee,K.R., and Kim,K.H. A new monoacylglycerol from the fruiting bodies of Gymnopilus spectabilis. J. Chem. Res., 40, 156-159 (2016.3) (2016)
- Woo,K.W., Cha,J.M., Choi,S.U., and Lee,K.R. A new triterpene glycoside from the stems of Lagerstroemia indica. Arch. Pharm. Res., 39, 631-635 (2016.5) (2016)
- K.H. Kim, S.U. Choi, Y.C. Kim, and K.R. Lee, Tirucallane triperpenoids from Cornus walteri, J. Nat. Prod., 74, 54-59. (2011)
- K.H. Kim, E. Moon, S.U. Choi, S.Y. Kim, and K.R. Lee, Biological evaluation of phenolic constituents from the trunk of Berberis koreana, Bioorg. Med. Chem. Lett., 21, 2270-2273. (2011)
- I.K. Lee, K.H. Kim, S.Y. Lee, S.U. Choi, and K.R.Lee, Three new megastigmane glucopyranosides from the cardamine komarovii, Chem. Pharm. Bull., 59(6) 773-777. (2011)
- M.C. Yang, H.C. Kwon, Y.J. Kim, K.R. Lee, and H.O. Yang, Oploxynes A and B, polycaetylenes from the stems of Oplopanax elatus, J. Nat. Prod., 73, 801-805. (2010)
- K.H. Kim, C.J. Piao, S.U. Choi, M.W. Son, and K.R. Lee, New cytotoxic tetrahydroprotoberberine-apophine dimeric and apophine alkaloids from Corydalis turtschaninovii, Planta Med., 76, 1732-1738. (2010)
수행과제
- 유독성 나무류 및 특이 천연자원으로부터 항암활성 천연물소재 발굴 기반 연구 (한국연구재단)
- 국내 자생 천연자원의 암세포 독성 성분 분리 및 구조 규명 (한국연구재단)
- 청대 구성성분 분리 및 구조 규명 연구
- 봉선화 흰꽃의 생리활성 성분 분리 및 구조 규명
연구부문
- Isolation and structural determination of bioactive natural products
- Cytotoxic constituents from natural sources
- Anti-dementia constituents from natural sources
- Anti-obesity constituents from natural source
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